– Wesley Kufel is clinical assistant professor (pharmacy practice) at Binghamton University, State University of New York

Vaccines help the immune system recognize viruses, typically by injecting weakened virus or the virus’s proteins. Pfizer and Moderna developed a new type of vaccine that instead uses mRNA, the molecular instructions for building virus

The first Coronavirus, aka Covid-19 vaccines have been authorised for use in the US, and states are starting to implement plans for who should get vaccinated first.

But one important group is absent: children.

So far, the vaccine is allowed only for adults and older teens. Testing is only now getting started with children — and just with adolescents. There are still a lot of unknowns.

As an infectious disease pharmacist and professor who helps manage patients hospitalized with Covid-19, I frequently hear questions about vaccines. Here’s what we know and don’t know in response to some common questions about vaccinating kids against this virus.

When can my child be vaccinated?

Right now, it appears unlikely that a vaccine will be ready for children before the start of the next school year in August.

Adult trials of the two leading vaccines have had promising results. The U.S. Food and Drug Administration issued emergency use authorization for both in mid-December, but only for use in adults and older teens. It authorised

Moderna’s vaccine for ages

18 and over on December 18, a week after authorizing Pfizer’s vaccine for ages 16 and older. Vaccines were already being injected in the UK, and Canada had authorised the Pfizer vaccine for the same age range.

But clinical trials involving children are only just getting started.

Pfizer, working with Germany’s BioNTech, expanded its Covid-19 vaccine testing to children aged 12 and older only in October. Moderna announced that it had just started trials with children ages 12-17 on December 10.

The vaccine’s efficacy and safety will have to be evaluated for each age group, and testing hasn’t started for infants, toddlers or kids in the US.

Clinical trials are designed to ensure that the vaccine is safe and effective. Typically, it takes 10-15 years from the start of development until a vaccine is licensed, but Covid-19 vaccines are being developed faster in response to the pandemic.

Will children need more shots than adults?

It does not seem that the schedule of Covid-19 vaccine doses will be different for children, but that could change as testing goes on.

Pfizer’s vaccine is being tested in adolescents with a two-dose series, three weeks apart, just as in adults. Moderna also plans to use its adult schedule — two doses four weeks apart — in a trial with 3,000 adolescents.

The second dose serves as a “booster shot”, since the first dose doesn’t provide optimal immunity. This is consistent with several other vaccines, including hepatitis B, measles, mumps and rubella.

Right now, only two doses are planned, but that could change. It’s unclear how long the immune response from these Covid-19 vaccines will last or if more doses will be necessary in the future. The flu vaccine, for example, requires a new dose every year because the virus mutates. Recent promising data from Moderna indicate immunity is sustained for at least three months after receiving the Covid-19 vaccine.

Are the vaccines safe for kids?

So far, no serious safety concerns have been identified with either the Pfizer or Moderna vaccines, but trials are still in the early stages for children. Several other vaccines are also under development around the world, and a few drugmakers have started trials with younger children in other countries.

One concern has been temporary side effects.

Children tend to have stronger immune systems than adults, and they may have stronger temporary reactions to the vaccine. That could mean greater pain and swelling at the injection site for a few days and possibly a fever.

These side effects are common with vaccines. They are evidence that the immune system is doing what it should be doing, but they can be scary.

In the UK, health officials warned on December 9 that anyone with a history of anaphylaxis shouldn’t get the vaccine after two adults with past experience of anaphylaxis had severe reactions.

The safety of the vaccine and likelihood of temporary side effects are important to understand, because adults and children will need two doses for the vaccine to provide optimal immunity.

Is vaccinating adults enough?

Just vaccinating adults won’t be enough to end the pandemic. Children can become infected, transmit the virus and develop complications. If a vaccine is not available, children will likely serve as a reservoir of the virus, making it harder to end the pandemic.

Both leading vaccines have reported promising results in adults so far: The efficacy rate is approximately 94 percent for Moderna’s vaccine and 95 percent for Pfizer’s. That means that under the best conditions, about 95 percent of adults who get the vaccine have been found to be protected. That’s higher than expected.

Whether the same holds for children remains to be seen.

Do we have to keep wearing masks and social distancing?

In the meantime, it will be important to continue standard preventive measures, including social distancing, wearing face masks, washing hands and following other official guidelines.

While the hope is that a vaccine will allow people to get back to a more ‘normal’ way of living, these preventive measures will still be needed, even after receiving the vaccine, until more information is known about the extent of protection provided by the vaccine.

There are still many unanswered questions. As time goes on, we’ll have more answers.

(This article is republished from The Conversation under a Creative Commons license)

Also read: Getting ready for reopened schools: 6 ways & means to boost child immunity